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PublicatioRecent Papers from the Laboratory



Vilas, G.L., Krishnan, D., Loganathan, S.K., Malhotra, D., Liu, L., Beggs, M., Gena, P., Calamita, G., Jung, M., Zimmermann, R., Tamma, G., Casey, J.R., and Alexander, R.T. (2015) Increased water flux induced by an interaction between aquaporin 1 and carbonic anhydrase II, Mol. Biol. Cell, 26, 1106-18.  Abstract.

Zoccola, D., Ganot, P., Bertucci, A., Caminiti-Segonds, N., Techer, N. Voolstra, C., Aranda, M., Tambutté, E., Allemand, D. Casey, J.R. and Tambutté, S. (2015) Bicarbonate Transporters in a Scleractinian Coral, Scientific Reports In Press.

Krishnan, D., Liu, L., Casey, J.R., Cordat, E., and Alexander, R.T. (2015) Carbonic Anhydrase II Binds to and Increases the Activity of the epithelial sodium/proton Exchanger, NHE 3  Am. J. Physiol., In Press.


Loganathan, S.K., and Casey, J.R. (2014) Corneal Dystrophy-Causing SLC4A11 Mutants: Suitability for Folding Correction Therapy, Human Mutation,35, 1082-91.

Soumittra, N., Loganathan, S.K., Madhavan, D., Ramprasad, V., Arokiasamy, T., Sumathi, S., Karthiyayani, T., Rachapalli, S., Kumaramanickavel, G., Casey J.R., and Rajagopal, R. (2014 )Biosynthetic and Functional Defects in Newly-identified SLC4A11 Mutants and Absence of COL8A2 Mutations in Fuchs Endothelial Corneal Dystrophy Journal of Human Genetics,59, 444-53.

Sowah, D., Brown, B.F., Quon, A., Alvarez, B.V., and Casey, J.R. (2014) Resistance to cardiomyocyte hypertrophy in ae3-/- mice, deficient in the AE3 Cl-/HCO3- exchanger, BMC Cardiovascular Disorders, In Press.

Casey, J.R. (2014) Report on the 57th annual meeting of the Canadian Society of Molecular Biosciences, Biochem. Cell Biol., 92, 425-6. Abstract

Alka, K. and Casey, J.R. (2014) Bicarbonate Transport in health and disease, IUBMB Life, 66, 596-615.   Abstract.



Pamela T Bonar, Hans-Peter Schneider, Holger M Becker, Joachim W Deitmer, Joseph Roman Casey, (2013) Three-Dimensional Model for the Human Cl-/HCO3- Exchanger, AE1, by Homology to the E. coli ClC Protein, Journal of Molecular Biology, 24, 2591-608.  Abstract

Vilas, G.L., Loganathan, S.K., Liu, J., Riau, A.K., Young, J.D., Mehta, J.S., Vithana, E.N. and Casey, J.R. (2013) Transmembrane water flux through SLC4A11: a route defective in genetic corneal diseases. Hum. Mol. Gent., 22, 4579-90. Abstract



Vilas, G.L., Loganathan, S., Quon, A.,, Sundaresan, P., Vithana, E.N and Casey, J.R. (2012) Oligomerization of SLC4A11 protein and the severity of FECD and CHED2 corneal dystrophies caused by SLC4A11 mutations, Human Mutation, 33, 419-428.  Abstract

B. Brown, A. Quon, J. Dyck and J.R. Casey (2012) Carbonic anhydrase II promotes cardiomyocyte hypertrophy Can. J. Physiol. Pharmacol.  90, 1599-610. Abstract

Alvarez, B.V., Quon, A., Mullen, J., and Casey, J.R. (2012) Quantification of Carbonic Anhydrase Expression in Hypertrophic and Failing Human Heart BMC Cardiovascular Disorders 13:2. Abstract




De Giusti, V., Orlowski, A., Villa-Abrille, M., Chiappe de Cingolani, G., Casey, J.R., Alvarez, B. and Aiello, E. (2011) Antibodies against the cardiac sodium bicarbonate cotransporter (NBCe1) as a pharmacolgical tool British Journal of Pharmacology, 164, 1976-1989.  Abstract

Vilas, G., Morgan, P., Loganathan, S., Quon A., and Casey, J.R. (2011)  A biochemical framework for SLC4A11, the plasma membrane protein defective in corneal dystrophies, Biochemistry , 50, 2157-69. Abstract

Johnson, D.E., and Casey, J.R. (2011) Cytosolic H+ microdomain developed around AE1 during AE1-mediated Cl-/HCO3- exchange, J. Physiology , 589, 1551-69 . Abstract

Sowah, D.., and Casey, J.R. (2011) An intrmolecular transport metabolon: Fusion of carbonic anhydrase II to the C-terminus of the Cl-/HCO3- exchanger, AE1, Am. J. Physiology, 301, C336-46.  Abstract

Reihmeier, R.A. and Casey J.R. (2011) Report on the 53rd annual meeting of  the Canadian Society of Biochemistry, Molecular and Cellular Biology: "Membrane Proteins in Health and Disease", Biochem. Cell Biol. 89, 79-81.  Abstract

Reithmeier, R.A. and Casey J.R. (2011) Report on the HCO3- transport satellite meeting at the 53rd annual meeting of the Canadian Society of Biochemistry, Molecular and Cellular Biology, Biochem. Cell Biol. 89, 83-84.  Abstract



Casey, J.R., Orlowski, J. and Grinstein, S. (2010) Sensors and Regulators of Intracellular pH Nature Reviews Molecular Cell Biology,11, 50-61.  Abstract

Bonar, P.T., and Casey, J.R. (2010) Purification of Functional Human Chloride/Bicarbonate Exchanger, AE1, Over-expressed in Saccharomyces cerevisiae Protein Expression and Purification, 74, 106-15.  Abstract

Basu, A., Mazor, S, and Casey, J.R. (2010) Distance measurements within a concatamer of the plasma membrane Cl-/HCO3- exchanger, AE1, Biochemistry, 49, 9226-40  Abstract



Cordat E., Casey J.R. (2009) Bicarbonate transport in cell physiology and disease. Biochem J. 417 423-39. Abstract

Johnson D.E., and Casey, JR (2009) Bicarbonate Transport Metabolons in Drug Design of Zinc Enzyme Inhibitors: Functional, Structural and Disease Applications, Supuran, C.T. and Winum, J., Eds, Wiley Chapter 20, pp. 415-437.

Johnson, D.E., AI, H.W., Wong, P., Young, J.D., Campbell, R.E. and Casey, J.R. (2009) Red fluorescent protein pH biosensor to detect concentrative nucleoside
transport, J. Biol. Chem. 284, 20499-511 Abstract

Vilas, Johnson, Freund, and Casey Characterization of an Epilepsy-associated variant of the AE3 Cl-/HCO3- exchanger (2009) Am. J. Physiol. 297, C526-36   Abstract

Casey, J.R., Sly, W.S., Shah, G.N., and Alvarez, B.V.(2009) Bicarbonate Homeostasis in Excitable Tissues: Roles of AE3 Cl-/HCO3- Exchanger and Carbonic Anhydrase XIV Interaction Am. J. Physiol. 297, C1091-102.  Abstract



Vithana, E.N, Morgan, P.E., Ramprasad, V., Tan, D.T.H., Yong, V.H.K., Venkataraman, D., Venkatraman, A., Yam, G.H.F., Nagasamy, S., Law, R.W.K., Rajagopal, R., Pang, C.P., Kumaramanickevel, G., Casey, J.R, Aung, T. (2008) SLC4A11 Mutations in Fuchs Endothelial Corneal Dystrophy (FECD) Hum. Mol. Genetics, 17, 656-666 . Abstract

Bonar P.T., Casey J.R. (2008) Plasma membrane Cl-/HCO3- exchangers: Structure, mechanism and physiology. Channels (Austin) 2, 337-345. Abstract



Alvarez, B.V., Kieller, D.M., Quon, A.L., Robertson, M.  and Casey J.R. (2007) Cardiac hypertrophy in Anion Exchanger 1 Null Mutant Mice with Severe Hemolytic Anemia, Am. J. Physiol, 292: H1301-12. Abstract 

 Alvarez, B.V., Johnson, D.E., Sowah, D., Soliman, D., Light, P.E., Xia, Y., Karmazyn, M. and Casey J.R. Carbonic Anhydrase Inhibition Prevents and Reverts Cardiomyocyte Hypertrophy (2007) J. Physiol, 579:127-45. Abstract  

Zhu, Q. and Casey J. R. (2007) Topology of Transmembrane Proteins by Scanning Cysteine Accessibility Mutagenesis Methodology, Methods, 41:439-450. Abstract

Shandro, H. and Casey, J.R. (2007) Plasma Membrane Chloride/Bicarbonate Exchangers in Chloride movements across cellular membranes Bittar, E Ed. Elsevier.

Alvarez, B.V., Shandro, H., Yang, Z., Vithana, E.N., Koh, A.H., Yeung, K., Yong, V., Kolatkar, P., Palasingam, P., Zhang, K., Aung T., and Casey J.R. (2007) Functional characterization of a novel carbonic anhydrase 4 mutation identified in a Chinese patient with retinitis pigmenetosa, Invest Ophthalmol Vis Sci,  48, 3459-68. Abstract

Morgan, P.E., Pastoreková, S., Stuart-Tilley, A. K., Alper S. L. and Casey, J. R. (2007) Interactions of Transmembrane Carbonic Anhydrase, CAIX, with Bicarbonate Transporters Am. J. Physiol, 293, C738-4 . Abstract

Keskanokwong, T., Shandro H.J., Johnson, D.E., Kittanakom, S., Vilas, G.L., Reithmeier, R.A.F., Varaporn, A., Yenchitsomanus, P., and Casey J.R. (2007) Interaction of Integrin-linked Kinase with kAE1 Cl-/HCO3- Exchanger, J. Biol. Chem, 282, 23205-18 . Abstract

Alvarez, B.V., Gilmour, G., Mema, S.C., Shull, G.E., Casey, J.R., Sauvé, Y. (2007) Blindness results from deficiency in AE3 chloride/bicarbonate exchanger PloS ONE, 2, e839. Abstract




Li X, Alvarez B, Casey JR, and Fliegel L (2006) A Novel Carbonic Anhydrase II Binding Site Regulates NHE1. Biochemistry 45: 2414-24. Abstract

Vithana EN, Morgan PE, Sundaresan P, Ebenezer N, Tan DTH, Anand S, Khine KO, Venkataraman D, Yong V, Salto-Tellez M, Venkataraman A, Guo K, Hemadevi B, Mohamed MD, Srinivasan M, Prajna V, Khine M, Casey JR, Inglehearn CF, and Aung T (2006) Mutations in Na+-bonate co-transporter SLC4A11 cause recessive Congenital Hereditary Endothelial Dystrophy CHED2. Nature Genetics 38: 755-7. Abstract

Casey, J.R. (2006) Why Bicarbonate?, Biochem. Cell Biol., 84: 930-939. Abstract



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