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University of Alberta
Faculty of Medicine & Dentistry
Research Programs

Structure and Function of Cl-/HCO3- Exchangers.
Supported by the Canadian Institutes of Health Research.

Developing a structural model for bicarbonate transporters is essential to understanding their transport mechanism and regulation at the molecular level.  The goal of this program is to determine a structural model for bicarbonate transporters, using the AE1 Cl-/HCO3- exchanger as a model.  We are using a broad range of biochemical approaches.
Topology model for human AE1 Cl-/HCO3- exchanger
Topology model for human AE1 Cl-/HCO3- exchanger

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