Research Publications

37. Chaulk, S., Thede, G.L., Kent, O.A., Xu, Z., Gesner, E., Veldhoen, R.A., Khanna, S.K., Goping, I.S., MacMillan, A.M., Mendell, J.T., Young, H., Fahlman, R., Glover, J.N.M."Role of pri-miRNA tertiary structure in miR-17~92 miRNA biogenesis" RNA Biol. 8 (2011) in press.

36. Gesner, E.M., Schellenberg, M.J., Garside, E.L., George, M.M., MacMillan "Recognition and maturation of effector RNAs in a CRISPR interference pathway" Nature Struct. Mol. Biol. published online 15 May 2011 [pdf file on request].

35. Schellenberg, M.J.; Dul, E.L., MacMillan. A.M. "Structural Model of the p14/SF3b155-Branch Duplex" RNA 17 155-165 (2011).[pdf file].

34. Schellenberg, M.J.; Ritchie, D.B., Wu, T., Markin, C.J., Spyracopoulos, L., MacMillan, A.M. "Context Dependent Remodeling of Structure in Two Large Protein Fragments" J. Mol. Biol. 402 720-730 (2010). [pdf file on request]

33. Ritchie, D.B., Schellenberg, M.J., MacMillan, A.M. "Spliceosome Structure: Piece by Piece" Biochim. Biophys. Acta 1789 624-633 (2009). [pdf file]

32. Kent, O.A.; MacMillan, A.M. "Proteins Specifically Modified with a Chemical Nuclease as Probes of RNA-Protein Interaction" in Methods Mol. Biol. 488 191-200 RNA-Protein Interaction Protocols, second edition (R.J. Lin, Ed.; Humana Press, Totowa, N.J., 2008). [pdf file on request]

31. Ritchie, D.B., Schellenberg, M.J., Gesner, E.M., Raithatha S.A., Stuart, D.T., MacMillan, A.M. "Structural elucidation of a PRP8 core domain from the heart of the spliceosome" Nature Struct. Mol. Biol. 15 1199-1205 (2008). [pdf file] [Supplementary pdf file]

30. Schellenberg, M.J.; Ritchie, D.B.; MacMillan, A.M. "Pre-mRNA splicing: a complex picture in higher definition" TiBS 33 243-246 (2008). [pdf file on request]

29. Chaulk, S.G.; MacMillan, A.M. "Synthesis of oligo-RNAs with photocaged adenosine 2'-hydroxyls" Nature Protocols 2 1052-1058 (2007). [pdf file]

28. Chilibeck, K.A.; Wu, T.; Liang, C.; Schellenberg, M.J.; Gesner, E.M.; Lynch, J.M.; MacMillan. A.M. "FRET Analysis of In Vivo Dimerization by RNA Editing Enzymes" J. Biol. Chem. 281 16530-16535 (2006). [pdf file]

27. Schellenberg, M.J.; Edwards, R.A.; Ritchie, D.B.; Oliver A. Kent, O.A.; Golas, M.M.; Stark, H.; Luhrmann, R.; Glover, J.N.M.; MacMillan, A.M. "Crystal Structure of a Core Spliceosomal Protein Interface" Proc. Natl. Acad. Sci. U.S.A. 5 1266-1271 (2006). [pdf file]

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26. Chaulk, S.G.; Kent, O.A.; MacMillan, A.M. "Photo-control of RNA Processing" in Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Biomolecules, (Goeldner, M. , Givens, R. Eds.), pp. 495-513 (Wiley-VCH Weinham, 2005). [pdf file]

25. Kent, O.A.; Ritchie, D.B.; MacMillan, A.M. "E': A Novel Commitment Complex in the Mammalian Spliceosome Assembly Pathway" Mol. Cell. Biol. 25 233-240 (2005). [pdf file] .

24. MacMillan, A.M. "Fifty Years of "Watson-Crick"" Pure Appl. Chem. 76, 1521-1524 (2004). [pdf file]

23. Kent, O.A.; MacMillan, A.M. "RNAi: Running Interference for the Cell" Org. Biomol. Chem. 2 1957-1961 (2004). [pdf file on request]

22. Kent, O.A.; Reayi, A.; Foong L.; Chilibeck K.A.; MacMillan, A.M. "Structuring of the 3' Splice Site by U2AF65" J. Biol. Chem. 278 50572-50577 (2003). [pdf file]

21. Jaikaran, D.C.J.; Collins, C.H.; MacMillan, A.M. "Adenosine to Inosine Editing by ADAR2 Requires Formation of a Ternary Complex on the GluR-B R/G Site" J. Biol. Chem. 277 37624-37629 (2002). [pdf file]

20. Kent, O.; MacMillan, A.M. "Early Organization of pre-mRNA During Spliceosome Assembly" Nature Struct. Biol. 9 576-581 (2002). [pdf file]

19. MacMillan, A.M. "From Equilibrium to Kinetic Footprinting of RNA Structure" J. Chem. Soc. Perkin Trans. 2, 8 1263-1267 (2001). [pdf file]

18. Chaulk, S.G.; MacMillan, A.M. "Separation of Spliceosome Assembly from Catalysis Using Caged pre-mRNA Substrates" Angew. Chemie Int. Ed., 40 2149-2152 (2001)/Angew. Chemie, 113 2207-2210 (2001). [pdf file]

17. Will, C.L.; Schneider, C.; MacMillan, A.M.; Katopodis, N.; Neubauer, G.; Wilm, M.; Lührmann, R.; Query, C.C. "A Novel U2 and U11/U12 snRNP Protein that Associates with the pre-mRNA Branch Site" EMBO J., 20 4536-4546 (2001). [pdf file]

16. Kent, O.; Chaulk, S.G.; MacMillan, A.M. "Kinetic Analysis of the M1 RNA Folding Pathway"J. Mol. Biol. 304 699-705 (2000). [pdf file]

15. Chaulk, S.G.; Pezacki, J.P.; MacMillan, A.M. "Development of a New Photochemical Footprinting Method. Studies of RNA Cleavage by Photolysis of N-Hydroxypyridine-2(1H)-thione" Biochemistry 39 10448-10453 (2000). [pdf file]

14. Jaikaran, D.C.J.; MacMillan, A.M. "Template-Directed Interference Footprinting for RNA Based on Inosine Specific Cleavage" Bioorg. Med. Chem. Lett. 10 1633-1635 (2000). [pdf file]

13. Chaulk, S.G.; MacMillan, A.M. "Kinetic Footprinting of an RNA Folding Pathway Using Peroxynitrous Acid" Angew. Chemie Int. Ed., 39 521-523 (2000)/Angew. Chemie, 112 531-533 (2000). [pdf file]

12. Chaulk, S.G.; MacMillan, A.M. "Characterization of the Tetrahymena Ribozyme Folding Pathway Using the Kinetic Footprinting Reagent Peroxynitrous Acid" Biochemistry, 39 2-8 (2000). [pdf file]

11. Pomeranz Krummel, D.A.; Kent, O.; MacMillan, A.M.; Altman, S. "Evidence for Helical Unwinding of an RNA Substrate by the RNA Enzyme RNase P: Use of an Interstrand Disulfide Crosslink in Substrate" J. Mol. Biol., 295 1113-1118 (2000). [pdf file]

10. Chaulk, S.G.; MacMillan, A.M. "Caged RNA: Photo-control of a Ribozyme Reaction" Nucleic Acids Res., 26 3173-3178 (1998). [pdf file]

9. MacMillan, A.M.; McCaw, P.S.; Crispino, J.D.; Sharp, P.A. "SC35 Mediated Reconstitution of Splicing in U2AF Depleted Nuclear Extract" Proc. Natl. Acad. Sci. U.S.A., 94 133-136 (1997). [pdf file]

8. MacMillan, A.M.; Query, C.C.; Allerson, C.A.; Chen, S.; Verdine, G.L.; Sharp, P.A. "Dynamic Association of Proteins with the pre-mRNA Branch Region" Genes Dev., 8 3008-3020 (1994). [pdf file]

7. Chen, L.; MacMillan, A.M.; Verdine, G.L. "Mutational Separation of DNA Binding from Catalysis in a DNA Cytosine Methyltransferase" J. Am. Chem. Soc., 115 5318-5319 (1993). [pdf file]

6. MacMillan, A.M.; Lee, R.J.; Verdine, G.L. "Direct Observation of a Specific Contact in the l Repressor-OL1 Complex by Isotope-edited NMR" J. Am. Chem. Soc., 115 4921-4922 (1993). [pdf file]

5. MacMillan, A.M.; Chen, L.; Verdine, G.L. "Synthesis of an Oligonucleotide Suicide Substrate for DNA Methyltransferases" J. Org. Chem., 57 2989-2991 (1992). [pdf file]

4. Chen, L.; MacMillan, A.M.; Chang, W.; Ezaz-Nikpay, K.; Lane, W.S.; Verdine, G.L. "Direct Identification of the Catalytic Nucleophile in a DNA Methyltransferase" Biochemistry, 30 11018-11025 (1991). [pdf file]

3. MacMillan, A.M.; Verdine, G.L. "Engineering Tethered DNA Molecules by the Convertible Nucleoside Approach" Tetrahedron, 47 2603-2616 (1991). [pdf file]

2. MacMillan, A.M.; Verdine, G.L. "Synthesis of Functionally Tethered Oligonucleotides by the Convertible Nucleoside Approach" J. Org. Chem., 55 5931-5933 (1990). [pdf file]

1. Brook, A.G.; MacMillan, A. "Silacyclopropanes from the Reaction of Silenes with Wittig Reagents" J. Organomet. Chem., 341 C9-C12 (1988). [pdf file]